Imara is developing IMR-687, an oral, once-a-day, potentially disease-modifying treatment for sickle cell disease (SCD) and beta-thalassemia. IMR-687 is a highly selective, potent small molecule inhibitor of PDE9.
IMR-687 for the treatment of sickle cell disease
Imara is currently conducting a Phase 2a randomized, double-blinded, placebo-controlled clinical trial of IMR-687 in adult patients with SCD. We have also initiated an open label extension trial, which allows patients from the Phase 2a clinical trial to continue into a long-term, four-year trial to evaluate safety and tolerability of IMR-687.